p53 Immunohistochemistry (IHC)
Use
The product of the p53 gene is a nuclear phosphoprotein that regulates cell proliferation. Excess accumulation of the mutant p53 gene product results in inactivation of its tumor suppressor function and cellular transformation. Overexpression of mutant p53 gene has been associated with high proliferative rates and poor prognosis in various cancers including breast, colon, lung, and brain cancer, as well as some leukemias and lymphomas.
Special Instructions
A formalin-fixed, paraffin-embedded (FFPE) tissue block is the preferred specimen type. Blocks and slide identifiers should match exactly with the specimen ID as noted on the requisition.
Limitations
Correct CPT coding is the responsibility of the billing party, and information is provided for informational purposes only.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Formalin-fixed, paraffin-embedded (FFPE) tissue block or unstained slides
Collection Instructions
Use cold pack for transport, ensuring it is not in direct contact with specimen. NYS clients must provide date and time of collection.