p57
Use
p57 (Kip 2, CDKN 1C) is an inhibitor of several G1 cyclin complexes and is a negative regulator of cell proliferation. The gene encoding human p57 is located on chromosome 11p15.5, a region implicated in sporadic cancers, Wilms tumor, and Beckwith‑Wiedemann syndrome (BWS), making it a tumor suppressor candidate. p57 expression is useful in differentiating complete hydatidiform mole (which shows no nuclear p57 expression) from partial hydatidiform mole or spontaneous abortion (which shows normal expression).
Special Instructions
Not provided.
Limitations
Not provided.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Result Turnaround Time
Not provided.
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
FFPE tissue block preferred; or one unbaked, unstained slide for H&E staining (required) plus two to three positively charged unstained slides, cut at 4–5 microns. Block and slide identifiers must match the requisition.
Storage Instructions
Use cold pack for transport, making sure cold pack is not in direct contact with specimen.