Pan-Cytokeratin
Also known as: CK AE1/AE3
Use
The Pan‑Cytokeratin immunohistochemistry (IHC) test uses a cocktail of monoclonal antibodies AE1 and AE3 recognizing acidic and basic subfamilies of cytokeratin, enabling broad detection of human epithelial cells. It is used in surgical pathology to identify carcinomas and other tumors with epithelial components or differentiation, aiding in distinguishing epithelial from non‑epithelial tumors.
Special Instructions
Global interpretation is available only for sentinel nodes. For Pan‑Cytokeratin performed on sentinel nodes, refer to Carcinoma Micromets testing.
Limitations
Not provided.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Result Turnaround Time
24 hours
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
A formalin‑fixed, paraffin‑embedded (FFPE) tissue block is preferred specimen type or one unbaked, unstained H&E slide (required) and 2‑3 positively charged unstained slides (cut at 4‑5 microns) per test/antibody ordered. Block and slide identifiers should match specimen ID on requisition.
Storage Instructions
Use a cold pack for transport, ensuring pack does not contact specimen. NYS clients provide date and time of collection.