PMS2
Use
PMS2, also known as PMS1 protein homologue 2, is a DNA mismatch repair (MMR) protein which forms a heterodimer with MLH1 and coordinates repair of DNA errors during cell division. Loss of PMS2 expression in tumors can aid in identifying hMLH1 mutation carriers. PMS2 gene defects contribute to a small but notable portion of colorectal cancers and a substantial subset of tumors exhibiting microsatellite instability.
Special Instructions
Not provided.
Limitations
Not provided.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
FFPE tissue block or unbaked unstained slide(s)
Collection Instructions
Preferred: FFPE tissue block; or one unbaked, unstained slide for H&E (required) plus 2-3 positively charged unstained slides cut at 4–5 microns; block and slide identifiers must match requisition.
Storage Instructions
Use cold pack for transport, but not in direct contact with specimen. NYS clients provide date and time of collection.