PSAP/HPAP
Also known as: Prostate Acid Phosphatase
Use
Prostate specific acid phosphatase (PSAP) / human prostatic acid phosphatase (HPAP) is a 100 kDa glycoprotein present in high concentration in the prostate gland and its secretions. PSAP is specific to benign or malignant epithelial cells of the prostate gland; prostatic stroma, urethra, and basal cells stain negatively. Injury to epithelial cells (inflammation, infarction) and squamous metaplasia leads to loss of PSAP activity. Nearly all metastases of prostatic carcinoma, regardless of site, demonstrate PSAP immunoreactivity.
Special Instructions
Not provided.
Limitations
Not provided.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
PSAP/HPAP
Protein
Result Turnaround Time
Not provided.
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
A formalin‑fixed, paraffin‑embedded (FFPE) tissue block is preferred specimen type or one unbaked, unstained slide for H&E staining (required) and two to three (2‑3) positively charged unstained slides (all cut at 4‑5 microns) for each test/antibody ordered. Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Storage Instructions
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.