Uroplakin III
Use
Uroplakins (UPs) are a family of transmembrane proteins (UPs Ia, Ib, II and III) that are specific differentiation products of urothelial cells. In non‑neoplastic urothelium, UPIII is expressed in the luminal surface plasmalemma of superficial (umbrella) cells. UPIII detects half of urothelial carcinomas, whereas many non‑urothelial carcinomas are UPIII‑negative. Recent studies of UP gene expression in normal urothelium and bladder cancer specimens found that UP expression was absent after malignant transformation. Thus, UP expression may reflect the malignant potential of urothelial cancer cells as well as serve as cytodifferential markers of urothelial cells.
Special Instructions
Not provided.
Limitations
Not provided.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Result Turnaround Time
24 hours
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Formalin‑fixed, paraffin‑embedded (FFPE) tissue block is preferred specimen type or one unbaked, unstained slide for H&E staining (required) and two to three positively charged unstained slides (all cut at 4‑5 microns) for each test/antibody ordered. Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Storage Instructions
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.