Myelin Oligodendrocyte Antibodies by Live Cell-Based Assay (MOG CBA)
Use
This test is used for the detection of myelin oligodendrocyte glycoprotein (MOG) antibodies to assist in the diagnosis of MOGAD (Myelin oligodendrocyte glycoprotein antibody-associated disease). It helps healthcare providers distinguish MOGAD from other similar medical conditions, thus aiding in targeted and effective patient management. The presence of MOG antibodies is associated with MOGAD, an immune-mediated inflammatory disorder. The test is conducted as part of a comprehensive evaluation in patients with suspected autoimmune neurological disorders.
Special Instructions
Not provided.
Limitations
This test, performed by BCNI, is a laboratory-developed test (LDT) carried out in compliance with DAP, CAP, and CLIA certification standards. Its performance characteristics were assessed by BCNI, and the test is intended for clinical purposes only. It's important to note that the presence of immunomodulating treatments in patients might interfere with test results, potentially leading to false positives or negatives.
Methodology
Cell-based / Cytometry (Flow Cytometry)
Biomarkers
Myelin Oligodendrocyte Glycoprotein Antibody
Antibody
Result Turnaround Time
7 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
5 mL
Minimum Volume
0.5 mL
Container
5 mL SST tube (gold-top)
Collection Instructions
No patient preparation is needed. Draw blood into SST tubes, invert 8 times for mixing, centrifuge at 1800 - 2200 x g for 10-15 minutes, draw off serum into aliquot tubes with pipette, avoiding gel or RBC layers.
Storage Instructions
Store aliquot tubes in a refrigerator (2°C - 8°C) until shipping. Ship on cold-packs same day as collection.
Causes for Rejection
Specimens that are grossly hemolytic, lipemic, icteric, or if the sample arrives at room temperature.
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | Up to 7 days refrigerated (2 - 8°C) |
| Frozen | -20°C for longer term storage – avoid subsequent freeze thaws |