DCISionRT
Use
DCISionRT is a tumor biology–based risk assessment assay used in patients with ductal carcinoma in situ (DCIS) following initial diagnosis to quantify 10-year recurrence risk and predict the benefit of radiation therapy after breast-conserving surgery. The test integrates protein biomarker expression with clinicopathologic factors using a non-linear algorithm to generate a personalized Decision Score (0–10), enabling more informed treatment decisions regarding the use of adjuvant radiation therapy.
Special Instructions
DCISionRT is ordered after initial diagnosis of DCIS and does not require a new specimen collection, as the performing laboratory retrieves archived tumor tissue from prior biopsy or surgical specimens. Providers submit an order (typically via fax), after which the laboratory coordinates specimen acquisition directly with the pathology department. Results are delivered to the ordering physician to support treatment planning discussions.
Limitations
DCISionRT is intended for use in patients with confirmed DCIS and should be interpreted in the context of clinical and pathologic findings. While the test provides individualized recurrence risk and predicted radiation benefit, it does not replace clinical judgment or established treatment guidelines. Additionally, performance depends on adequate tumor tissue availability and quality from archived specimens, and results reflect probabilistic risk rather than definitive outcomes.
Methodology
Immunoassay (IHC)
Biomarkers
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Tumor Tissue (FFPE)
Volume
Sufficient tumor tissue from prior DCIS biopsy or surgical specimen
Minimum Volume
Not specified publicly
Container
FFPE tissue block preferred; unstained slides acceptable
Collection Instructions
No new specimen collection is required. Submit archived FFPE tumor tissue from the diagnostic biopsy or breast-conserving surgery specimen. PreludeDx coordinates specimen retrieval with the pathology department after the physician order is submitted.
Storage Instructions
Store FFPE tissue at room temperature under standard pathology archive conditions prior to shipment.
Causes for Rejection
- Insufficient tumor tissue - Inadequate tissue quality - Unavailable archived specimen - Improper specimen type - Damaged or compromised block/slides