Lynch Syndrome/Constitutional Mismatch Repair Deficiency Panel
Use
This test is designed for individuals with relevant clinical features and a suspected diagnosis of Lynch syndrome or constitutional mismatch repair deficiency. It is particularly aimed at individuals diagnosed with colorectal or endometrial cancer before the age of 50, or those with multiple Lynch syndrome-related cancers in first- or second-degree relatives diagnosed before age 50. Patients with tumor testing indicating microsatellite instability or loss of MMR protein expression are also candidates for this test. The panel covers 5 genes associated with these conditions.
Special Instructions
Not provided.
Limitations
This test has not been cleared or approved by the US Food and Drug Administration. Only those tests developed and validated by PreventionGenetics under CAP and CLIA guidelines can be performed at their laboratory in Wisconsin. The test provides a comprehensive analysis of the covered genes, but may not detect all genetic variants related to Lynch syndrome or constitutional mismatch repair deficiency.
New York Approved
Methodology
NGS (Targeted)
Biomarkers
Result Turnaround Time
14-21 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Standard procedures should be followed for the collection of blood samples.