Use

This test is for individuals with relevant features who have a clinical or suspected diagnosis of Lynch syndrome or constitutional mismatch repair deficiency, particularly those diagnosed with colorectal or endometrial cancer before age 50. It is also applicable for individuals with multiple Lynch syndrome-related cancers in close relatives diagnosed before age 50, those with tumor testing indicating microsatellite instability or loss of MMR protein expression, and individuals with negative PMS2 sequencing results but still showing clinical features of Lynch syndrome.