Casandra
Casandra Test Code QD47997Version 1 (DRAFT)
Performing Lab
Beta2‑Adrenergic Receptor Mutations
Clinical Use
Order TestUse
This test detects two polymorphisms in the beta‑2 adrenergic receptor (ADRB2) gene: Gly16Arg and Gln27Glu, which have been shown to correlate with the phenotype of bronchodilator responsiveness in asthma.
Special Instructions
Not provided.
Limitations
This assay does not test for the presence of mutations in other regions of the ADRB2 gene that could contribute to drug response or disease. In addition, this assay does not test for non‑genetic causes of drug response or disease. Some individuals with poor response to these drugs, or respiratory disease, may have other chromosomal or DNA abnormalities not detected by this test.
Test Details
Methodology
PCR-based (PCR)
Biomarkers
ADRB2
GeneSNV/Indel • Mutation • Categorical (e.g., Positive / Negative / Indeterminate)
Result Turnaround Time
9 days
Related Documents
For more information, please review the documents below
Specimen Requirements
Specimen
Whole Blood
Volume
5 mL
Minimum Volume
3 mL
Container
EDTA (lavender‑top) tube
Collection Instructions
Normal phlebotomy procedure.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 8 days |
| Refrigerated | 8 days |
| Frozen | Unacceptable |