Chromosomal Microarray, Postnatal, ClariSure® Oligo-SNP
Also known as: Microarray, Genomic Alterations, ClariSure® Oligo-SNP Array, Oligo-SNP Array Genomic Alteration, ClariSure® Genomic Alterations
Use
The ClariSure® Oligo‑SNP Postnatal chromosomal microarray (CMA) utilizes an oligonucleotide‑SNP format with over 2.6 million probes—including 1.9 million copy‑number probes and 750,000 SNP probes—and analyzes genomic DNA to detect copy number variants, regions of homozygosity suggestive of uniparental disomy or consanguinity, and chromosomal syndromes, particularly in the evaluation of congenital anomalies, developmental delay, intellectual disability, or autism spectrum disorders.
Special Instructions
Not provided.
Limitations
This assay cannot reliably detect low‑level mosaicism; balanced rearrangements including Robertsonian or reciprocal translocations and inversions; Fragile X syndrome; single‑gene sequence‑level disorders (e.g., Marfan syndrome, neurofibromatosis); or deletions/duplications below the assay’s resolution threshold. Small regions of homozygosity below approximately 10 Mb may not be identified.
Methodology
Other
Biomarkers
Result Turnaround Time
10-14 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5 mL whole blood (preferred)
Minimum Volume
3 mL (standard); 0.5 mL for critical NICU/neonates
Container
Sodium heparin tube (green‑top); also acceptable: sodium heparin (royal blue‑top), sodium heparin lead‑free (tan‑top), or EDTA (lavender‑top)
Collection Instructions
Whole blood; Critical NICU/Neonates 0.5 mL; all others 3‑5 mL