Chromosome Analysis, Amniotic Fluid, Reflex to ClariSure® Oligo‑SNP, Prenatal
Also known as: Amnio, SNP array, ClariSure®, Karyotype, Prenatal
Use
Testing determines chromosomal status of the fetus. Numerical and structural chromosomal abnormalities can be diagnosed. Sex and the presence of more than one cell line (mosaicism) can also be determined. Indications include diagnosis of chromosome abnormalities in fetuses of women who are of advanced maternal age; had a previous child with a chromosome abnormality; parental carrier of a balanced translocation, inversion or marker chromosome; parental mosaicism and follow‑up for abnormal maternal serum alpha‑fetoprotein or maternal screening results. If Chromosome Analysis, Amniotic Fluid is normal, then the Chromosomal Microarray, Prenatal, ClariSure® Oligo‑SNP will be performed at an additional charge.
Special Instructions
Physician Attestation of Informed Consent required; signed informed consent required for New York; amniotic fluid kit and handling instructions available on request; do not reject specimen; patient age, gestational age, and indication(s) required; do not split tubes even if AFP requested; supernatant will be split by cytogenetics lab; reflex microarray at additional charge.
Limitations
Not provided.
Methodology
Chromosomal / Cytogenetics (Karyotype)
Biomarkers
Result Turnaround Time
6-8 days
Related Documents
For more information, please review the documents below
Specimen
Amniotic Fluid
Volume
30 mL
Minimum Volume
10 mL
Container
sterile tube
Collection Instructions
Fresh amniotic fluid; do not split tubes even if AFP requested; supernatant split by cytogenetics lab
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Preferred |
| Refrigerated | Acceptable |
| Frozen | Unacceptable |