Chromosome Analysis and AFP with Reflex to AchE, Fetal Hgb, and Oligo‑SNP

Use

Testing determines chromosomal status of the fetus. Numerical and structural chromosomal abnormalities can be diagnosed. Sex and the presence of more than one cell line (mosaicism) can also be determined. Indications include diagnosis of chromosome abnormalities in fetuses of women who are of advanced maternal age; had a previous child with a chromosome abnormality; parental carrier of a balanced translocation, inversion or marker chromosome; parental mosaicism and follow‑up for abnormal maternal serum alpha fetoprotein or maternal screening results. Chromosomal Microarray, Prenatal, ClariSure® Oligo‑SNP – This assay may be useful for further investigation on fetuses with abnormal ultrasound findings indicating congenital malformation; further definition of an imbalanced cytogenetic abnormality; further investigation on equivocal cytogenetic findings; attempt at characterization of supernumerary marker chromosome; follow‑up to a documented chromosome abnormality or genomic alteration in a sibling or a parent; family history of a previous child with mental retardation and/or phenotypic abnormalities.