Chromosome Analysis, Solid Tumor
Use
Chromosome Analysis, Solid Tumor is a cytogenetic test intended to identify acquired chromosomal abnormalities associated with solid tumors. It analyzes metaphase chromosomes from cultured tumor tissue to detect structural and numerical aberrations that may inform diagnosis and prognosis.
Special Instructions
Requires living tumor tissue cultured in transport medium; sample must remain unfrozen and viable. Insurance authorization may be required for outpatient orders; inpatients may proceed. Specimen handling details—including tissue culture medium, transport temperature, and rejection criteria—must be adhered to.
Limitations
Results depend on successful culture of viable tumor cells and may be affected by culture failure. Does not detect submicroscopic abnormalities (e.g., microdeletions/microduplications) below cytogenetic resolution or low-level mosaicism. Tumor heterogeneity may lead to missing subclonal abnormalities.
Methodology
Chromosomal / Cytogenetics (Karyotype)
Biomarkers
Result Turnaround Time
10-12 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (Unknown)
Volume
Not provided
Minimum Volume
Not provided
Container
Quest Genetics Transport Pack or sterile tissue culture medium or sterile saline
Collection Instructions
Tumor tissue collected in genetics transport pack; moist and sterile; biopsy size minimum 3×3 mm
Storage Instructions
Refrigerate; do not freeze
Causes for Rejection
Received frozen; specimens in non‑sterile fluids/containers
Stability Requirements
| Temperature | Period |
|---|---|
| Frozen | Unacceptable |