Drug Monitoring, Alcohol Metabolite, with Confirmation, Urine
Also known as: Prescription Drug Monitoring, Pain Management
Use
This urine-based test is designed to assess recent exposure to ethanol by detecting its metabolites, ethyl glucuronide (EtG) and ethyl sulfate (EtS). The measurement of both EtG and EtS improves specificity: EtS—unlike EtG—does not appear to be produced in vitro by bacteria in the specimen, ensuring a more reliable indication of in vivo alcohol intake. The test interprets EtG concentrations ≥500 ng/mL as positive only when accompanied by EtS concentrations ≥100 ng/mL, minimizing false positives. Use of both biomarkers supports accurate clinical monitoring of abstinence or alcohol exposure.
Special Instructions
Not provided.
Limitations
Incidental exposure to alcohol—that is, via non-beverage sources like ethanol-based hand sanitizers—can still trigger positive results, as the LC-MS/MS detection method identifies EtG and EtS regardless of origin. EtG may be produced in vitro if ethanol-producing bacteria are present in urine; to counter this, EtS is required to meet threshold for positivity. Interpretation should always consider clinical context and possible incidental exposures.
Methodology
Mass Spectrometry
Biomarkers
Ethyl Glucuronide (EtG)
AnalyteEthyl Sulfate (EtS)
Analyte
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
Not provided
Minimum Volume
7 mL
Container
clinical drug test transport vial (random urine); sterile leak‑proof urine container acceptable
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
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