ER/PR, Paraffin Block
Also known as: Progesterone Receptor, ER/PR, Estrogen Receptor, ERA/PRA
Use
Determination of estrogen receptor (ER) and progesterone receptor (PR) expression on formalin‑fixed, paraffin‑embedded tumor tissue is essential in breast cancer management. ER is a key predictive biomarker guiding benefit from endocrine therapies, while PR indicates estrogen pathway functionality and may provide additional prognostic information.
Special Instructions
Submit a formalin‑fixed, routinely processed paraffin‑embedded tissue block, along with one H&E‑stained histologic section and five unstained freshly cut sections on positively charged slides. Do not oven‑dry unstained slides. Include completed Test Requisition, original requisition, and pathology report. Indicate collection date/time, cold ischemia time, fixative type (if not formalin), and fixation duration. Ship blocks wrapped individually in cooled container; slides at ambient or cool temperature.
Limitations
Not provided.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Result Turnaround Time
Not provided.
Related Documents
For more information, please review the documents below
Specimen
Tissue
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Formalin‑fixed paraffin‑embedded tissue block; one H&E‑stained section plus five unstained cut sections on positively charged slides; do not oven‑dry unstained slides; avoid decalcification, freezing or crush artifacts.
Storage Instructions
Wrap blocks individually and transport in cooled container with frozen gel ice packs or dry ice; slides may be transported at cool or ambient temperature.