Use

The Factor VIII Inhibitor Panel (test code 40083) is used to detect and quantify inhibitors (alloantibodies or autoantibodies) against factor VIII, which may occur in patients with congenital hemophilia A undergoing replacement therapy or in acquired hemophilia. Low factor VIII activity triggers reflex testing: a chromogenic IgG antibody screen and, if positive, quantification by the Nijmegen‑Bethesda assay to determine inhibitor titer in Bethesda Units (BU), reflecting the functional inhibitory activity.