FISH – AML/MDS 7q31 Deletion (Monosomy 7)
Use
Fluorescence in situ hybridization (FISH) is used to detect monosomy 7 or deletions of the 7q31 locus, abnormalities associated with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). This assay aids in diagnosing myeloid disorders and in clinical decision-making when correlated with other diagnostic information.
Special Instructions
Not provided.
Limitations
A negative FISH result does not rule out other chromosomal abnormalities. This assay should be used as an adjunct to chromosome analysis and other diagnostic modalities. Appropriate interpretation requires consideration of clinicopathologic context.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Result Turnaround Time
4-6 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow
Volume
0.5–1.0 mL
Minimum Volume
0.5 mL
Container
sodium heparin
Collection Instructions
Early aspirate bone marrow from 1st or 2nd aspirate.
Storage Instructions
Store and transport at room temperature; DO NOT FREEZE; may transport with coolant during hot weather.
Causes for Rejection
Clotted or hemolyzed specimens; frozen specimens; plasma or serum.