Use

This fluorescence in situ hybridization (FISH) assay uses a break‑apart probe to detect the API2/MALT1 (BIRC3/MALT1) fusion gene resulting from the t(11;18) translocation. Detection of this translocation aids in the diagnosis of extranodal marginal zone lymphoma of mucosa‑associated lymphoid tissue (MALT lymphoma), which is frequently associated with the BIRC3/MALT1 fusion. The presence of this fusion may have implications for resistance to H. pylori eradication therapy and indicates disease dissemination, particularly in gastric MALT lymphoma.