FISH, p53, Deletion 17p13.1
Use
This fluorescence in situ hybridization (FISH) assay detects deletion of the TP53 gene region in chromosome 17p13.1. The results of this test may aid in the prognostic assessment and treatment selection for chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). The most common genetic abnormalities of CLL/SLL include del(13q), del(11q), trisomy 12, and del(17p).
Special Instructions
Clinical history and reason for referral is required with test order. Prior therapy and transplant history should be provided. Specify if run for plasma cell neoplasms. If results are not possible, order may be canceled and replaced with a Cytogenetics Communication.
Limitations
Not provided.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Result Turnaround Time
5 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow
Volume
3 mL preferred; 1 mL minimum
Minimum Volume
1 mL
Container
sodium heparin (green‑top) tube
Storage Instructions
Room temperature for most specimens; fresh lymph node refrigerated