FISH, Prenatal Screen
Also known as: Aneuploidy Screen, AneuVysion™, FISH, Prenatal Screen, FISH
Use
This fluorescence in situ hybridization (FISH) assay screens for numerical chromosomal abnormalities associated with common prenatal aneuploidies, including trisomy 13, trisomy 18, trisomy 21 (Down syndrome), and sex chromosome abnormalities such as Turner syndrome, Klinefelter syndrome, and triploidy. It does not detect other chromosome aneuploidies, structural abnormalities, or low‑level mosaicism. A positive FISH result should be confirmed by chromosome analysis or supported by consistent clinical information before irreversible therapeutic decisions are made.
Special Instructions
Not provided.
Limitations
This assay does not screen for chromosome abnormalities other than chromosomes 13, 18, 21, X, and Y. Structural chromosomal abnormalities and low‑level mosaicism will not be detected. Irreversible clinical decisions should not be based solely on FISH results — confirmatory chromosome analysis or clinical correlation is recommended.
Methodology
Chromosomal / Cytogenetics
Biomarkers
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Amniotic Fluid
Volume
20 mL (5 mL minimum)
Minimum Volume
5 mL
Container
sterile, screw‑cap container
Collection Instructions
Amniotic fluid: 20 mL in a sterile container
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