FISH, RUNX1T1/RUNX1 (ETO/AML1), Translocation (8;21)
Also known as: AML, AML1/ETO-FISH, AML-M2 FISH, Acute Myeloid Leukemia
Use
This test is performed to detect the RUNX1T1 (ETO;8q22) and RUNX1 (AML1;21q22), translocation t(8;21), by FISH. It is clinically useful for the diagnosis of acute myeloid leukemia (AML) with RUNX1T1/RUNX1 (ETO/AML1) gene fusion.
Special Instructions
Clinical history and the reason for referral are required with the test order. Prior therapy and transplant information should be submitted with the order. Specimen viability decreases during transit; do not freeze and do not reject. If results are not possible, the test order may be canceled and replaced by a Cytogenetics Communication.
Limitations
Not provided.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Result Turnaround Time
5 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5 mL whole blood (preferred) or 3 mL bone marrow
Minimum Volume
1 mL
Container
sodium heparin (green-top) tube; also acceptable royal blue-top or tan-top sodium heparin tube
Collection Instructions
See instructions: clinical history required; do not freeze; maintain viability during transit