HOXB13 Sequencing and Deletion/Duplication
Also known as: Inherited Cancer, HOXB, Prostate Cancer
Use
This test detects single-nucleotide variants, deletions, and duplications in the HOXB13 gene, which codes for the transcription protein homeobox protein HOXB13. It may be indicated for individuals with a personal or family history of prostate cancer. Positive results indicate detection of pathogenic or likely pathogenic variants; negative results indicate none detected. Variants of uncertain significance (VUS) reflect insufficient evidence and may require periodic reclassification. Genetic counseling is strongly recommended for informed consent and interpretation. Surveillance and management recommendations can refer to NCCN guidelines for prostate cancer. ([questdiagnostics.com](https://www.questdiagnostics.com/healthcare-professionals/clinical-education-center/faq/hoxb13-sequencing-and-deletion-duplication?utm_source=openai))
Special Instructions
Not provided.
Limitations
Turnaround time may be delayed by incomplete orders or insurance authorization. A negative result does not rule out pathogenic variants outside the analyzed regions or other hereditary cancer syndromes; interpretation depends on personal and family history. VUS results have unclear significance and require clinical context and possible family studies. Variant classification may change over time; annual review for updates is advised. ([questdiagnostics.com](https://www.questdiagnostics.com/healthcare-professionals/clinical-education-center/faq/hoxb13-sequencing-and-deletion-duplication?utm_source=openai))
Methodology
NGS
Biomarkers
HOXB13
Gene
Result Turnaround Time
14-21 days
Related Documents
For more information, please review the documents below
Specimen
Other
Volume
Not provided
Minimum Volume
Not provided
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