HOXB13 Sequencing and Deletion/Duplication

Casandra

Casandra Test Code QD06544Version 1 (DRAFT)

Performing Lab

Lab Quest DiagnosticsLab Test ID 38807CPT Code 81479

HOXB13 Sequencing and Deletion/Duplication

Also known as: Inherited Cancer, HOXB, Prostate Cancer

Clinical Use

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Use

This test detects single-nucleotide variants, deletions, and duplications in the HOXB13 gene, which codes for the transcription protein homeobox protein HOXB13. It may be indicated for individuals with a personal or family history of prostate cancer. Positive results indicate detection of pathogenic or likely pathogenic variants; negative results indicate none detected. Variants of uncertain significance (VUS) reflect insufficient evidence and may require periodic reclassification. Genetic counseling is strongly recommended for informed consent and interpretation. Surveillance and management recommendations can refer to NCCN guidelines for prostate cancer. ([questdiagnostics.com](https://www.questdiagnostics.com/healthcare-professionals/clinical-education-center/faq/hoxb13-sequencing-and-deletion-duplication?utm_source=openai))

Special Instructions

Sample reports and information regarding specific variants analyzed are available on QuestHereditaryCancer.com. If a familial mutation is known, the Hereditary Cancer Single Site(s) test (code 93945) may be considered. Official familial test results must be available for review. Genetic counseling is available via Quest Genomics Client Services. Insurance coverage will be verified upon order receipt; if patient responsibility exceeds $100, notification will occur before initiation. ([questdiagnostics.com](https://www.questdiagnostics.com/healthcare-professionals/clinical-education-center/faq/hoxb13-sequencing-and-deletion-duplication?utm_source=openai))

Limitations

Turnaround time may be delayed by incomplete orders or insurance authorization. A negative result does not rule out pathogenic variants outside the analyzed regions or other hereditary cancer syndromes; interpretation depends on personal and family history. VUS results have unclear significance and require clinical context and possible family studies. Variant classification may change over time; annual review for updates is advised. ([questdiagnostics.com](https://www.questdiagnostics.com/healthcare-professionals/clinical-education-center/faq/hoxb13-sequencing-and-deletion-duplication?utm_source=openai))

Test Details