HPV mRNA E6/E7, Post‑Hysterectomy, Vaginal
Use
Detects presence of oncogenic HPV E6/E7 messenger RNA from 14 high‑risk HPV genotypes in post‑hysterectomy vaginal specimens. Expression of these oncogenes is associated with cervical cancer risk and indicates active infection, potentially more specific than HPV DNA testing and reducing unnecessary interventions such as colposcopy or biopsy.
Special Instructions
Validated only for post‑hysterectomy vaginal specimens collected in PreservCyt® ThinPrep® vials (3 mL preferred, 1.5 mL minimum). Use of collection medium and tube type critical.
Limitations
More specific than DNA testing but may not identify individual genotypes unless reflex testing is ordered separately. Interpretation limited to detection of E6/E7 transcripts; does not genotype unless reflex performed. Not suitable for non‑validated specimen types.
Methodology
Other
Biomarkers
Result Turnaround Time
2-4 days
Related Documents
For more information, please review the documents below
Specimen
Vaginal Swab
Volume
3 mL
Minimum Volume
1.5 mL
Container
ThinPrep® vial containing PreservCyt® transport medium