Use

This test is used to identify individuals with Lynch syndrome (hereditary non‑polyposis colorectal cancer, HNPCC) by analyzing five key genes — MLH1, MSH2, MSH6, PMS2, and EPCAM (with EPCAM deletions disrupting MSH2 transcription). It is indicated for individuals with personal or family histories of Lynch-associated cancers or with evidence of mismatch repair deficiency via MSI or IHC, or a ≥2.5 % risk per predictive models. Informed consent after genetic counseling is strongly recommended.

Not provided.