Casandra
Casandra Test Code QD71278Version 1 (DRAFT)
Performing Lab
MLH1, IHC with Interpretation
Also known as: MMR=mismatch repair, Hereditary Nonpolyposis Colon Cancer (HNPCC), Lynch Syndrome
Clinical Use
Order TestUse
This immunohistochemistry (IHC) assay is based on an antibody directed against the DNA mismatch repair (MMR) protein MLH1; it detects the presence or absence of MLH1 protein expression in tumor tissue which can aid in identifying Lynch syndrome and assessing MMR deficiency.
Special Instructions
Not provided.
Limitations
Not provided.
Test Details
Methodology
Immunoassay (IHC)
Biomarkers
MLH1
ProteinIHC • Expression • Ordinal Score (e.g., TPS, CPS, H-score)
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen Requirements
Specimen
Tumor Tissue (Fixed (Non-FFPE))
Volume
Not provided
Minimum Volume
Not provided
Container
Formalin-fixed paraffin embedded tissue in an IHC specimen transport kit; or 4‑micron unstained slides (x5); fixed tissue in neutral buffered formalin
Collection Instructions
Pathology report is required
Storage Instructions
Room temperature indefinite
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Indefinite |
| Refrigerated | Indefinite |
| Frozen | Unacceptable |