MPL Mutation Analysis
Also known as: Myeloproliferative neoplasm, PMF, Essential Thrombocythemia (ET), Polycythemia Vera (PV), ET
Use
Detects mutations in exon 10 of the MPL gene, including the common W515 and S505 codons, which are associated with myeloproliferative neoplasms (MPNs) including primary myelofibrosis and essential thrombocythemia. Identification of these mutations assists in differentiating reactive conditions from MPNs.
Special Instructions
Testing may be ordered separately or as part of the MPN Reflex Panel. New York State clients must provide date and time of collection. If specimen hold is desired, select "Extract & Hold ‑ DNA" service when ordering. Ship specimens same day as drawn; use cold pack (not touching specimen) for transport.
Limitations
This assay is designed to detect sequence variants (mutations) only and is not intended for the detection of copy number changes or gene rearrangements.
New York Approved
Methodology
NGS (Targeted)
Biomarkers
Result Turnaround Time
10 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow
Volume
2 mL
Minimum Volume
Not provided
Container
EDTA tube
Storage Instructions
Use cold pack for transport; do not place cold pack in direct contact with specimen. Ship same day as drawn.