Multiple Sclerosis Panel
Use
The Multiple Sclerosis Panel aids in the evaluation of suspected multiple sclerosis by detecting myelin basic protein and oligoclonal IgG bands in cerebrospinal fluid, which are associated with demyelinating processes characteristic of MS. It provides supportive evidence for diagnosis when interpreted alongside clinical and imaging findings.
Special Instructions
Both CSF and serum specimens are required. It is preferred that collection date and time coincide for both samples, though collected within 48 hours is acceptable. If serum is not provided, client will be contacted. CSF collection should preferably be from lumbar puncture tube #4 to minimize blood contamination.
Limitations
The panel is limited by requirement for both CSF and serum; adequacy of specimen volume and timing is critical. Blood contamination of CSF may interfere with results, and hemolysis or xanthochromia can cause rejection. Interpretation must consider potential confounders; results alone do not confirm diagnosis and must be integrated with clinical context.
Methodology
Immunoassay (RIA)
Biomarkers
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
2.2 mL CSF
Minimum Volume
1.2 mL CSF
Container
sterile tube #4
Collection Instructions
CSF collected in sterile tube #4 is preferred to minimize blood contamination. Both CSF and serum required; collection dates/times preferably same or within 48 hours.
Causes for Rejection
Hemolysis in CSF; Xanthochromia/RBCs in CSF
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 8 Hours |
| Refrigerated | 14 Days |
| Frozen | 21 Days |