Use

Globally, about 2 billion people are infected with Mycobacterium tuberculosis complex (MTB). In 2010, 8.8 million people developed active disease and 1.4 million people died due to the illness. In the United States in 2012, 9,951 new cases of tuberculosis were reported (3.2 cases per 100,000) with 536 deaths attributed to TB infections. Treatment regimens are typically effective but MTB strains resistant to first-line drugs require tailored therapy. Rifampin resistance often indicates multidrug resistant TB (MDR‑TB), which includes resistance to rifampin and isoniazid. In the U.S., rifampin resistance occurs in approximately 1.8% of strains, and of those, about 90% are also resistant to isoniazid.