Use

This test detects single‑nucleotide variants, deletions, and duplications in the PALB2 gene, which encodes the tumor suppressor protein partner and localizer of BRCA2. Pathogenic and likely pathogenic variants in PALB2 are associated with autosomal dominant increased risk for breast cancer and pancreatic cancer; appropriate for individuals with personal or family history of these cancers; genetic counseling and informed consent are strongly recommended. ([questdiagnostics.com](https://www.questdiagnostics.com/healthcare-professionals/clinical-education-center/faq/faq253?utm_source=openai))