QNatal® Advanced

Casandra

Casandra Test Code QD35612Version 1 (DRAFT)

Performing Lab

Lab Quest DiagnosticsLab Test ID 92777

Also known as: NIPT

Clinical Use

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Use

QNatal® Advanced is a noninvasive cell‑free DNA (cfDNA) prenatal screening test performed on maternal blood, designed to assess risk for common fetal chromosomal aneuploidies—including trisomy 21 (Down syndrome), trisomy 18 (Edwards syndrome), trisomy 13 (Patau syndrome), sex chromosome abnormalities (e.g., monosomy X, XXY, XXX, XYY), and, if elected, selected microdeletion syndromes (1p36, 4p, 5p, 8q, 11q, 15q, 22q) and fetal sex. It is intended as a screening tool—not diagnostic—and positive or increased‑risk results should be followed by genetic counseling and diagnostic testing when clinically indicated. It should not be used prior to 10 weeks gestation.

Special Instructions

This test is performed on cell‑free DNA (cfDNA) isolated from maternal blood, sequenced using massively parallel shotgun sequencing (MPSS) with quantitative bioinformatics analysis. Fetal sex and microdeletion testing options may be elected or opted out by provider/patient.

Limitations

QNatal® Advanced is a screening—not diagnostic—test and cannot detect copy number abnormalities outside its target chromosomes or regions or nonsyndromic congenital anomalies such as neural tube defects or ventral wall defects. Results may be affected by low fetal fraction; false positives and negatives may occur due to factors such as confined placental mosaicism, vanishing twin, fetal or maternal mosaicism, fibroids, or maternal malignancy.

Test Details