Quest AD‑Detect™ Apolipoprotein E (ApoE) Isoform, Plasma
Also known as: Amyloid imaging abnormalities, Alzheimer's Disease (AD), ApoE2, ApoE3, ApoE4
Use
Apolipoprotein E (ApoE) is a well‑defined genetic risk factor for late‑onset Alzheimer’s disease (AD). The human APOE gene has three polymorphic alleles, E2, E3 and E4 that result in six different genotypes. Approximately half of AD patients carry the E4 allele (vs 14 % in the general population), with E4 dosage correlated with higher disease risk and lower age of onset. Differences between isoforms arise from two amino acids altering protein structure and lipid‑amyloid‑β interactions; circulating plasma and CSF ApoE levels are emerging as AD biomarkers relevant to brain amyloid pathology, complementing beta‑amyloid testing.
Special Instructions
Not provided.
Limitations
Not provided.
Methodology
Mass Spectrometry
Biomarkers
ApoE isoform
Protein
Result Turnaround Time
3-10 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
1 mL (0.5 mL minimum)
Minimum Volume
0.5 mL
Container
K2 EDTA (lavender‑top) tube
Collection Instructions
Centrifuge specimen and transfer plasma to a 12 × 75 mm polypropylene tube
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 14 days |
| Frozen | 32 days |
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