Casandra
Casandra Test Code QD18820Version 1 (DRAFT)
Performing Lab
Tacrolimus and Sirolimus, LC/MS/MS (NY)
Clinical Use
Order TestUse
Tacrolimus (FK506) and Sirolimus (Rapamycin) are immunosuppressive drugs used in organ transplantation to prevent graft rejection. Therapeutic drug monitoring is useful to optimize dose and avoid toxicity.
Special Instructions
Includes both tacrolimus and sirolimus testing together; specimen requirement and methodology same as individual assays; New York patient testing only—use this code for NY patients; for non‑NY patients the individual assays should be used separately.
Limitations
Not provided.
Test Details
Methodology
Mass Spectrometry
Biomarkers
Sirolimus
AnalyteSirolimus • Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)
Tacrolimus
AnalyteTacrolimus • Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen Requirements
Specimen
Whole Blood
Volume
4 mL
Minimum Volume
2 mL
Container
EDTA (lavender‑top) tube
Collection Instructions
Collect specimen 1 hour prior to next dose (12 hour trough)
Causes for Rejection
Clotted
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 5 days |
| Refrigerated | 7 days |
| Frozen | 30 days |