ZAP‑70
Also known as: Flow, Zeta-chain Associated Protein
Use
ZAP‑70 expression is reported only in the CD5+/CD19+ cells and serves as an important prognostic marker in chronic lymphocytic leukemia (CLL), functioning as a surrogate for immunoglobulin-variable-region mutation status and aiding in risk stratification and patient management. ([questdiagnostics.com](https://www.questdiagnostics.com/healthcare-professionals/clinical-education-center/faq/faq41?utm_source=openai))
Special Instructions
When only FFPE bone marrow tissue is available, ZAP‑70 can be evaluated using immunohistochemistry (IHC) under test code 90192. Flow cytometry on blood, bone marrow aspirate, or fresh tissue is the method for standard testing. ([questdiagnostics.com](https://www.questdiagnostics.com/healthcare-professionals/clinical-education-center/faq/faq41?utm_source=openai))
Limitations
Not provided.
Methodology
Immunoassay (IHC)
Biomarkers
Result Turnaround Time
Not provided.
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
Not provided
Minimum Volume
Not provided