1,3-Beta-D-Glucan (Fungitell), Serum

Casandra

Casandra Test Code MC63750Version 1 (DRAFT)

Performing Lab

Lab Mayo Clinic LabLab Test ID SFUNGCPT Code 87449

1,3-Beta-D-Glucan (Fungitell), Serum

Clinical Use

Use

The 1,3-Beta-D-Glucan (Fungitell) test aids in diagnosing invasive fungal infections caused by various fungi, including Aspergillus species, Fusarium species, Candida species, and Pneumocystis jirovecii. It is especially useful for patients at risk for such infections, like those with hematologic or immune deficiencies, transplant recipients, and patients undergoing hemodialysis. The test detects circulating (1,3)-beta-D-glucan in serum, which is a component of the cell walls of many fungi. The presence of elevated levels of this biomarker suggests an active fungal infection.

Special Instructions

Avoid exposure of the specimen to the atmosphere to prevent environmental contamination. Centrifuge and send the entire specimen in the original collection tube without aliquoting or opening the tube. If not ordering electronically, print and send one of the following forms with the specimen: General Request (T239), Microbiology Test Request (T244), or Kidney Transplant Test Request. The assay should be used alongside other diagnostic tests, including cultures, histologic examinations, and radiologic findings.

Limitations

The BDG assay does not detect fungi such as Cryptococcus species, Blastomyces species, and Mucorales, which do not produce (1,3)-beta-D-glucan. False-positive results may occur following recent hemodialysis, use of certain blood products, or exposure to glucan-containing gauze. Single time-point testing is less reliable than serial testing, which is recommended to improve diagnostic accuracy and monitor disease progression. The BDG assay does not identify specific fungal organisms. Diagnosis should be performed in conjunction with other clinical evaluations and tests.

Test Details

FDA Approved