6-Monoacetylmorphine, Chain of Custody, Random, Urine
Use
This test is used for the determination of recent heroin use. 6-Monoacetylmorphine (6-MAM) is a unique metabolite of heroin with a very short detection window, typically only detectable within 24 hours of use. The presence of 6-MAM in urine is definitive for recent heroin use, as it is rapidly metabolized and converted to morphine. The chain of custody process is important for legal testing situations as it maintains specimen integrity, ensuring it can withstand court scrutiny.
Special Instructions
Chain of custody is required whenever results may be used in court. Specimen collection involves using a Chain-of-Custody Kit, ensuring proper documentation and the integrity of the specimen throughout the testing process. This test also includes additional testing for adulterants due to regulatory requirements.
Limitations
The absence of 6-MAM does not rule out heroin use due to its short half-life. While 6-MAM is a definitive indicator of recent heroin use, morphine may also be found in specimens as it is a subsequent metabolite. Therefore, presence of morphine alone is not sufficient to confirm heroin use. Gross hemolysis and icterus are acceptable, which may affect other tests, but 6-MAM detection is reliable under these conditions.
New York Approved
Methodology
Mass Spectrometry (GC-MS)
Biomarkers
LOINC Codes
- 19593-3
- 19593-3
- 69050-3
- 77202-0
Result Turnaround Time
3-7 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
10 mL
Minimum Volume
2.1 mL
Container
Chain-of-Custody Kit
Collection Instructions
Collect the specimen in the container provided, seal it, and submit with the associated documentation to satisfy the legal requirements for chain-of-custody testing.
Storage Instructions
Refrigerated (preferred) up to 14 days; Ambient for up to 72 hours; Frozen for up to 14 days.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 14 days |
| Frozen | 14 days |