Adenosine Deaminase, RBC
Use
Adenosine deaminase (ADA) deficiency is an autosomal recessive disorder of purine metabolism primarily affecting lymphocyte development, viability, and function. Lack of ADA allows deoxyadenosine to accumulate and kill lymphocytes. This test is useful as a marker of severe combined immunodeficiency (SCID).
Special Instructions
Not provided.
Limitations
Affected individuals have less than 1% of normal adenosine deaminase (ADA) catalytic activity in red cell hemolysates. ADA deficiency is the cause of 20% to 30% of severe combined immunodeficiency (SCID) cases. Heterozygotes cannot be identified by this test. If the patient has been recently transfused, adenosine deaminase (ADA) deficiency may be masked; interpret results with caution.
Methodology
Other
Biomarkers
Adenosine Deaminase
Analyte
LOINC Codes
- 47549-1 - Adenosine deaminase RBC-cCnt
- 47549-1 - Adenosine deaminase RBC-cCnt
Result Turnaround Time
3-8 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
1 mL
Minimum Volume
0.5 mL
Container
Lavender top (EDTA), pink top (K2 EDTA), or green top (sodium or lithium heparin)
Collection Instructions
Send 1 mL whole blood, refrigerate.
Causes for Rejection
Hemolysis
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 15 days |
| Refrigerated | 15 days |