Aldosterone, LC/MS, Two Specimens

Casandra

Casandra Test Code LC43543Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 237537CPT Code 82088

Aldosterone, LC/MS, Two Specimens

Clinical Use

Use

This test is intended for the measurement of aldosterone levels in two separate specimen samples collected from a patient. Aldosterone is a hormone produced by the adrenal glands that helps regulate blood pressure by controlling sodium and potassium levels in the blood. This test can aid in the diagnosis of conditions such as hyperaldosteronism and help in monitoring aldosterone production in patients undergoing treatment. The use of LC/MS (liquid chromatography-mass spectrometry) ensures high sensitivity and specificity for the aldosterone measurement.

Special Instructions

This is a series panel requiring multiple tubes to be drawn at different times. Initial tube is collected (baseline), followed by a treatment (e.g., medication or glucose ingestion), then subsequent tubes are collected post-treatment. The series should not commence without clinician consultation to confirm the order.

Limitations

This test requires multiple specimens collected at different times, so it may not be suitable for patients unable to comply with this collection schedule. The test has not been cleared or approved by the FDA, which may limit its clinical validity and utility. Potential pre-analytical issues such as improper specimen handling or timing could affect the test results. Cross-reactivity and specificity limitations inherent to mass spectrometry technology may also exist.

Test Details

Methodology

Mass Spectrometry

Biomarkers

Aldosterone #1

Analyte

Aldosterone #1 • Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

Aldosterone #2

Analyte

Aldosterone #2 • Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

LOINC Codes

Order Codes

27988-5

Result Codes

27988-5
46963-5
43604-8

Result Turnaround Time

4-6 days

Specimen

Serum

Volume

3 mL

Minimum Volume

2 mL

Container

Two serum separator tubes (SST) collected at different times.

Collection Instructions

Collect two specimens: the initial and another post-treatment (e.g., pill, shot, or glucola) sample. Ensure time-point accuracy to ensure reliable results.