Allergen Profile With Component Reflexes, Respiratory–Area 10

Casandra

Casandra Test Code LC02241Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 607025CPT Codes 82785, 86003

Allergen Profile With Component Reflexes, Respiratory–Area 10

Clinical Use

Use

Detect possible allergic responses to various substances in the environment (see Test Includes) and evaluate for hay fever, asthma, atopic eczema, and respiratory allergy. The quantitative allergen-specific IgE test is indicated (1) to determine whether an individual has elevated allergen-specific IgE antibodies; (2) if specific allergic sensitivity is needed to allow immunotherapy to be initiated; (3) when testing individuals for agents that may potentially cause anaphylaxis; (4) when evaluating individuals who are taking medication (eg, long-acting antihistamines) that may interfere with other testing modalities (eg, skin testing); (5) if immunotherapy or other therapeutic measures based on skin testing results have not led to a satisfactory remission of symptoms; (6) when an individual is unresponsive to medical management where identification of offending allergens may be beneficial.

Special Instructions

The test includes reflex testing for specific components if certain allergen IgE levels are equal to or higher than 0.35 kU/L. For example, if Dog IgE levels are ≥0.35 kU/L, additional tests for Can f 1 to Can f 6 will be conducted. Similarly, if Cat IgE levels meet this criterion, tests for Fel d 1, Fel d 2, Fel d 4, and Fel d 7 will be performed. This reflex testing strategy helps in a more precise allergen component diagnosis.

Limitations

The limitations of the test include the potential for cross-reactivity among allergens, which may complicate the interpretation of results. Additionally, IgE testing alone can sometimes give false positives or negatives, and must be evaluated in conjunction with clinical history and current symptoms. It should not be solely relied upon for diagnosis without further clinical correlation and assessment. Variability in patient response and environmental exposure can also influence the results.

Test Details