Alpha-1-Microglobulin, 24 Hour, Urine
Use
Alpha-1-microglobulin is used to assess renal tubular injury or dysfunction using 24-hour urine collections. It is a low-molecular-weight protein that is synthesized in the liver and reabsorbed by renal proximal tubules. Increased levels in urine can indicate tubular injury due to diseases or exposure to nephrotoxic substances. It is also useful for screening for tubular abnormalities and detecting chronic asymptomatic renal tubular dysfunction.
Special Instructions
No added preservative is preferred for urine collection. Specimens should be collected over 24 hours and mixed well before taking a 4-mL aliquot. A renal diagnostics test request form should accompany the specimen if not ordered electronically.
Limitations
Turbidity and particles in the specimen can interfere with nephelometric assays. Gross hemolysis of the specimen is a cause for rejection. The presence of turbidity or interfering substances can affect the accuracy of immunochemical reactions used in the test.
FDA ApprovedNew York Approved
Methodology
Immunoassay (Immunonephelometry)
Biomarkers
LOINC Codes
- 99075-4
- 2162-6
- 20624-3
- 13362-9
- 3167-4
- 48414-7
- 99076-2
- 99075-4
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
4 mL
Minimum Volume
1 mL
Container
Plastic, 5-mL tube
Collection Instructions
Collect urine for 24 hours. No added preservative preferred. Mix well before taking 4-mL aliquot.
Storage Instructions
Refrigerate within 4 hours of completion. Stable for 7 days at ambient, refrigerated, or frozen temperatures.
Causes for Rejection
Gross hemolysis
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 7 days |
| Frozen | 7 days |