Alpha-2-Antiplasmin, Activity
Also known as: ALPHA 2A
Use
This test is used to screen for alpha-2-antiplasmin deficiency. It's not a first-line test for diagnosing inherited thrombotic or bleeding disorders. Alpha-2-antiplasmin is a protein that inhibits fibrinolysis by inhibiting plasmin. Deficiency can lead to bleeding tendencies due to increased fibrinolytic activity.
Special Instructions
Refer to Specimen Handling at aruplab.com for detailed instructions, especially regarding hemostasis/thrombosis. Critical frozen storage is necessary for specimens. Separate specimens must be submitted for multiple tests ordered.
Limitations
This test uses a chromogenic assay which may have limitations in sensitivity and specificity for detecting alpha-2-antiplasmin activity. False results may occur if the specimen is not handled correctly, particularly if not kept frozen. Hemolyzed or clotted samples are unacceptable.
New York Approved
Methodology
Other
Biomarkers
LOINC Codes
- 27810-1
Result Turnaround Time
1-8 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
1 mL
Minimum Volume
0.5 mL
Container
ARUP standard transport tube
Collection Instructions
Transfer 1 mL platelet-poor plasma to an ARUP standard transport tube. Collect in Lt. blue (sodium citrate) tube.
Storage Instructions
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.
Causes for Rejection
Serum, EDTA plasma, clotted or hemolyzed specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 4 hours |
| Refrigerated | Unacceptable |
| Frozen | 3 months |
Other tests from different labs that may be relevant