AML::ETO; t(8;21)
Use
FISH test on hematologic specimens for detection of RUNX1::RUNX1T1 gene fusion. This fusion, associated with t(8;21), is commonly observed in acute myeloid leukemia, specifically in cases of acute myelogenous leukemia, AML(M2). It is an essential test for diagnosing and managing patients with this type of leukemia.
Special Instructions
Not provided.
Limitations
The test is specific for the RUNX1::RUNX1T1 fusion and may not detect other genetic abnormalities present in hematologic malignancies. Specimens that are clotted, exposed to extreme temperatures, or contain anticoagulants toxic to cells may be rejected. An insufficient number of cells may also lead to test rejection.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
No genes
Gene
Result Turnaround Time
5 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5 mL
Minimum Volume
Not provided
Container
EDTA preferred (NaHep accepted)
Storage Instructions
2°C to 25°C
Causes for Rejection
Clotted specimen; Specimen exposed to extreme temperature; Anticoagulant toxic to cells; Insufficient number of cells
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |