Anti-bestrophin Autoantibodies
Use
The Anti-bestrophin Autoantibodies test is used primarily for diagnosing and monitoring certain autoimmune diseases affecting the eye. Bestrophin is a protein found in the retinal pigment epithelium, and the presence of antibodies against it may indicate ocular autoimmune pathology. This test helps in differentiating other causes of eye inflammation or pathologies and assists in guiding treatment strategies for autoimmune retinopathy or related conditions.
Special Instructions
Ensure that the OHSU Ocular request form is completed and submitted alongside the specimen. Include the clinical history and referring physician's information, as the absence of these documents may delay or invalidate the test results.
Limitations
This test might not detect all forms of anti-retinal antibodies, and false negatives may occur if the concentration of antibodies is below the sensitivity threshold of the assay. Additionally, the presence of antibodies detected by this test does not always correlate with disease severity or progression, and results should be interpreted in the clinical context. Cross-reactivity with other proteins might lead to false positives.
New York Approved
Methodology
Immunoassay (Immunoblot)
Biomarkers
Result Turnaround Time
16-35 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
5 mL
Minimum Volume
3 mL
Container
Plastic vial
Collection Instructions
Draw blood in a plain, red-top tube(s), serum gel tube(s) is acceptable. Spin down and send 5 mL serum refrigerated in a plastic vial.
Storage Instructions
Refrigerated
Causes for Rejection
Mild hemolysis may cause rejection; gross hemolysis will cause rejection. Warm samples will be rejected.
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 7 days |