Antimullerian Hormone, Serum

Casandra

Casandra Test Code MC94598Version 1 (DRAFT)

Performing Lab

Lab Mayo Clinic LabLab Test ID AMH1CPT Code 82166

Antimullerian Hormone, Serum

Clinical Use

Use

Antimullerian hormone (AMH), also known as Mullerian-inhibiting substance, is a dimeric glycoprotein important for assessing ovarian status, including ovarian reserve and responsiveness, particularly in the context of infertility and assisted reproduction. It is also involved in the assessment of menopausal status, evaluation of ambiguous genitalia in infants, and testicular function in children. Monitoring AMH levels is critical in individuals with AMH-secreting ovarian granulosa cell tumors and can serve as a marker for ovarian granulosa cell tumors, comprising 10% of ovarian tumors. Additionally, AMH measurement is useful in evaluating disorders of sexual development and male fertility conditions.

Special Instructions

If not ordering electronically, complete, print, and send a General Request form with the specimen. Ensure blood samples are centrifuged and serum aliquoted into a plastic vial for submission.

Limitations

AMH immunoassays can vary and non-standardized values between different assay methods cannot be used interchangeably. Drugs such as Cetrotide, Ovitrelle, Endometrin, and follistatin may interfere with this test. Biotin concentrations up to 1200 ng/mL do not interfere with the assay. Antibodies to animal antibodies or streptavidin may cause interference. Results should be interpreted alongside clinical findings. High-dose AMH concentrations (up to 1400 ng/mL) do not result in a hook effect in the assay, and the presence of interfering substances or improper collection can affect results.

Test Details

New York Approved