Aspartate Aminotransferase (AST/SGOT)

Casandra

Casandra Test Code LC51197Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 001123CPT Code 84450

Aspartate Aminotransferase (AST/SGOT)

Also known as: Serum Glutamic Oxaloacetic Transaminase, SGOT, Transaminases

Clinical Use

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Use

A wide range of disease entities alters AST (SGOT), with origin from many organs. When an increased AST is from the liver, it is more likely to relate to disease of the hepatocyte. Other enzymes, including alkaline phosphatase and GT, are more sensitive indicators of biliary obstruction.

Special Instructions

Specimen should be separated from cells within 45 minutes of collection to ensure accurate results. It is important to maintain the specimen at room temperature until processing. The test uses serum (preferred) or plasma from a red-top, gel-barrier, or green-top (lithium heparin) tube.

Limitations

Limitations of the AST test include its non-specificity; elevated AST levels can arise from various conditions affecting organs other than the liver, such as the heart or muscles. Other enzymes like alkaline phosphatase and gamma-glutamyl transferase (GGT) may provide more sensitive indications of biliary obstruction. The presence of macroenzyme variants can cause unexplained elevations of AST levels, and certain drugs can also falsely elevate AST levels. Additionally, the interpretation of AST must often be done in combination with ALT and other liver function tests to provide a more comprehensive assessment of liver health.

Test Details