Use

This test is used for detecting deficiencies in the alternative pathway that can cause atypical Hemolytic Uremic Syndrome (aHUS), dense deposit disease, and C3 glomerulonephritis. It serves as a second-tier test aiding in the differential diagnosis of thrombotic microangiopathies (TMA), a group of disorders characterized by thrombosis in small blood vessels, which leads to microangiopathic hemolytic anemia, thrombocytopenia, and organ damage. Identifying the complement system dysfunction helps in the effective management of these conditions, especially in differentiating aHUS from other forms of TMA, thus avoiding unnecessary treatments and facilitating targeted therapies.