BAP1
Also known as: BRCA1-associated protein 1
Use
BAP1 IHC stain is used to detect BAP1 mutations via protein loss; loss of BAP1 by immunohistochemistry is 100% specific for malignant mesothelioma versus mesothelial hyperplasia, though loss may be seen in other neoplasms (mesothelioma context).
Special Instructions
Not provided.
Limitations
Not provided.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
BAP1
Protein
Result Turnaround Time
1 day
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type or one unbaked, unstained slide for H&E staining (required) and two to three (2‑3) positively charged unstained slides (cut at 4‑5 microns) for each test/antibody ordered. Block and slide identifiers should be clearly written and match exactly with specimen ID and requisition.
Storage Instructions
Use cold pack for transport, ensuring cold pack is not in direct contact with specimen.