BCL6
Use
BCL6 is a proto-oncogene mainly expressed in germinal center B-cells. In several subtypes of non-Hodgkin lymphomas (NHL), a translocation occurs which juxtaposes the BCL6 gene at 3q27 resulting in BCL6 overexpression, which can be detected via immunohistochemistry (IHC).
Special Instructions
Not provided.
Limitations
Stated turnaround times (TATs) are for clinical use only and subject to change based on biopharma protocol requirements. Final TATs will be specified in the biopharma study contract. Specimens must be fixed in 10% NBF or B plus. All other fixatives will be rejected.
Methodology
Immunoassay (IHC)
Biomarkers
BCL-6
Protein
Result Turnaround Time
2 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (Fresh)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Fixative should be at a 20:1 fixative to tissue ratio, 10% neutral buffered formalin (NBF) for 6-72 hours (48-72 hours PREFERRED).
Storage Instructions
15°C to 25°C
Causes for Rejection
Specimens must be fixed in 10% NBF or B plus. All other fixatives will be rejected.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | ≤ 72 Hours |