Biliary Tract Malignancy-Cytology, FISH, Varies
Use
This test is useful for assessing bile duct brushing or hepatobiliary brushing specimens for bile tract malignancy. It is performed in conjunction with endoscopic retrograde cholangiopancreatography (ERCP) to examine patients with biliary tract obstruction or stricture when malignancy is suspected. Cytologic analysis complements biopsy by sometimes detecting malignancy in patients with a negative biopsy, and FISH provides additional sensitivity in detecting chromosomal changes indicative of malignancy.
Special Instructions
Not provided.
Limitations
A positive FISH result does not identify the location or type of malignancy. FISH abnormalities may be associated with high-grade dysplasia or carcinoma in situ. The overall sensitivity of bile duct brushing and bile aspirate cytology is quite low; however, the use of FISH can increase sensitivity. Interpretative reports should be confirmed by clinical observation, repeat cytology, or biopsy in cases of suspicious or atypical results.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
LOINC Codes
- 95230-9 - Biliary Neo Chrom-Cyt Analysis Tiss
- 33724-6 - Collection method
- 22633-2 - Path report.site of origin Spec
- 22636-5 - Path report.relevant Hx Spec
- 8100-0 - Specimen preparation
- 80398-1 - Unique ID Current sample
- 69965-2 - Clinical cytogeneticist review
- 19139-5 - Pathologist name
- 35265-8 - Path Report.addendum Spec
- 22634-0 - Path report.gross Spec
- 62364-5 - Test performance info Spec
Result Turnaround Time
7-10 days
Related Documents
For more information, please review the documents below
Specimen
Other
Volume
Entire collection
Minimum Volume
Not provided
Container
Separate ThinPrep vial containing 20 mL PreservCyt or CytoLyt solution for each specimen
Collection Instructions
Label with site specimen was collected from (e.g., right hepatic duct or common bile duct).
Causes for Rejection
Pancreatic mass, Pancreatic cyst, Pancreatic fine-needle aspiration (FNA)
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | Refrigerated (preferred) |